【Abstract】 Vitiligo is a common skin pigmentation disease, and the molecular mechanism of melanocyte damage in skin lesions has not been clarified. The pathogenesis of the disease is complex, involving genetic, immune, oxidative stress, melanocyte self-destruction, psycho-nerve and other hypotheses. At present, the more respected view is that vitiligo is a complex disease of multi-gene inheritance mode, and the pathogenesis is not fully understood, and further research is needed.